Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina

Abstract Astronauts exhibit an assortment of clinical abnormalities in their eyes during long-duration spaceflight. The purpose this study was to determine whether spaceflight induces epigenomic and transcriptomic reprogramming the retina or alters epigenetic clock. mice were flown for 37 days animal enclosure modules on International Space Station; ground-based control animals maintained under similar housing conditions. Mouse retinas isolated both DNA methylome transcriptome determined by deep sequencing. We found that a large number genes differentially methylated with spaceflight, whereas there fewer expressed at level. Several biological pathways involved retinal diseases such as macular degeneration significantly altered. Our results indicated decelerated This demonstrates impacts levels, changes could be etiology eye-related disorders among astronauts.